Searchable abstracts of presentations at key conferences in endocrinology

ea0022p734 | Steroid metabolism & action | ECE2010

Muscle fiber conduction slowing and decreased levels of circulating muscle proteins after short-term dexamethasone administration in healthy subjects

Lanfranco Fabio , Minetto Marco Alessandro , Botter Alberto , Baldi Matteo Domenico , Motta Giovanna , Ghigo Ezio , Arvat Emanuela

Context: Glucocorticoids are known to decrease protein synthesis and impair membrane excitability of muscle fibres. However, their short-term effects on muscle structure and function of healthy subjects remain poorly understood.Objective: To investigate whether steroid administration could decrease the circulating levels of muscle proteins and modify myoelectric indexes of sarcolemmal excitability and fatigability.Design: Single-bl...

ea0016p634 | Reproduction | ECE2008

Leydig cells activity is impaired in patients with Sertoli cell-only syndrome

Baldi Matteo , Luetjens Marc Craig , Tuettelmann Frank , Nieschlag Eberhard , Simoni Manuela

Sertoli cell-only syndrome (SCOS) is characterized by a lack of germ cells and thickened seminiferous tubule walls and is a frequent finding among men with non-obstructive azoospermia. Spermatogenesis is dependent upon the function and number of Sertoli cells (SC) to support the developing germ cells. Klinefelter syndrome is the most frequent genetic cause of SCOS and presents histological features in common with idiopathic SCOS. Aim of this study was to analyze the relationsh...

ea0014p646 | (1) | ECE2007

Hormonal and seminal parameters in patients with testicular neoplasia or lymphoproliferative disorders: two year follow up

Di Bisceglie Cataldo , Bertagna Angela , Lanfranco Fabio , Baldi Matteo , Barberis Anna Maria , Zurzolo Lucrezia , Manieri Chiara

Semen quality and reproductive hormones may be affected in men with testicular neoplasia (TN) and lymphoproliferative disorders (LD). We evaluated these parameters before, 6, 12 and 24 months after the end of the oncological treatments in 60 patients with TN, and in 35 patients with LD. The patients were divided on the bases of the basal sperm concentration (A< and B≥ 10 million/ml). FSH, LH, testosterone (T) and inhibin B levels and sperm parameters were evaluated i...

ea0016p137 | Clinical cases | ECE2008

A novel compound heterozygous mutation of the aromatase gene in adult man: new insight into the role of estrogen on gonadal development

Lanfranco Fabio , Zirilli Lucia , Baldi Matteo , Luberto Alessandra , Pignatti Elisa , Magnani Francesca , Aimaretti Gianluca , Carani Cesare , Rochira Vincenzo

We present a novel heterozygous compound inactivating mutation of the CYP19A1 (P450arom) gene in a 26-year-old 46-XY Caucasian Italian male leading to aromatase deficiency. The patient phenotype resembled those observed in the other estrogen-deficient patients: tall stature with continuing linear growth, bilateral genu valgum, unfused epiphyses and delayed bone age, osteopenia. A dysmetabolic syndrome characterized by overweight (BMI 29), hyperinsulinaemia, low serum HDL and i...

ea0014p619 | (1) | ECE2007

Varicocele sclerotherapy improves serum inhibin B levels and seminal parameters

Baldi Matteo , Bisceglie Cataldo Di , Lanfranco Fabio , Bertagna Angela , Tagliabue Milena , Gazzera Carlo , Gandini Giovanni , Manieri Chiara

Varicocele is a state of varicosity and tortuosity of the pampiniform plexus around the testis caused by retrograde blood flow. The association between varicocele and male subfertility has been questioned, thus the usefulness of treating varicocele in order to improve fertility is still a matter of debate. Inhibin B levels reflect the functional state of the seminiferous epithelium, and have been found to be a sensitive index of spermatogenesis. Serum inhibin B levels have bee...

ea0014p622 | (1) | ECE2007

Ghrelin effects on spontaneous and stimulated LH secretion in human males

Bonelli Lorenza , Baldi Matteo , Broglio Fabio , Bertagna Angela , Di Bisceglie Cataldo , Tagliabue Milena , Manieri Chiara , Ghigo Ezio , Lanfranco Fabio

Acylated ghrelin (AG) participates in the modulation of the hypothalamic-pituitary-gonadal axis functions, with a predominantly inhibitory effect upon the reproductive system in animals. Animal studies have shown that ghrelin suppresses LH secretion in vivo, decreases LH responsiveness to GnRH in vitro and partially delays the timing of puberty in males. Aim of this study was to evaluate the effects of AG infusion on spontaneous and stimulated gonadotropin secret...